Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

Nat Neurosci.
Authors
Katharina Gapp, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar,Julien Prados, Laurent Farinelli, Eric Miska, and Isabelle M Mansuy
06-18-2014
12:00pm
PST
Categories
Small Noncoding RNAs in Eukaryotes
Speaker
Henok Eyob
Abstract
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.